Polymeric Gene Delivery: Principles and ApplicationsMansoor M. Amiji CRC Press, 2004年9月29日 - 704 頁 To treat disease or correct genetic disorders using gene therapy, the most suitable vehicle must be able to deliver genes to the appropriate tissues and cells in the body in a specific as well as safe and effective manner. While viruses are the most popular vehicles to date, their disadvantages include toxicity, limited size of genes they can carry |
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activity adenovirus amine antibody antisense applications binding Bioconj biodegradable Biol block copolymers cancer carrier cationic lipids cationic polymers cells cellular charge ratio Chem chitosan collagen condensation conjugates Control cross-linked cytotoxicity degradation dendrimers DNA complexes DNA delivery drug delivery effect encapsulated encoding endosomal endothelial enhanced Figure formulation gene delivery gene delivery systems gene expression Gene Ther gene therapy gene transfer genetic hydrogels immune response increase injection interaction intracellular intravenous ligands liposomes liver luciferase lung macromolecules matrices mediated membrane mice microspheres modified molecular weight molecules naked DNA nanoparticles nanospheres nonviral gene nuclear oligonucleotides PAAs PAMAM particles pDNA PEGylated peptide Pharm plasmid plasmid DNA PLGA Pluronic poloxamers polycations polyelectrolyte polyethylenimine polylysine polymeric polyplexes potential protein receptor specific stability stent structure studies surface synthesis synthetic targeting therapeutic tissue toxicity transfection transfection efficiency transgene expression tumor uptake vaccine vascular viral vectors virus vitro vivo gene