Polymeric Gene Delivery: Principles and ApplicationsMansoor M. Amiji CRC Press, 2004年9月29日 - 704 頁 To treat disease or correct genetic disorders using gene therapy, the most suitable vehicle must be able to deliver genes to the appropriate tissues and cells in the body in a specific as well as safe and effective manner. While viruses are the most popular vehicles to date, their disadvantages include toxicity, limited size of genes they can carry |
其他版本 - 查看全部
常見字詞
acid activity addition adenovirus administration applications approach binding block cancer carrier cationic cells cellular charge Chem chitosan compared complexes concentration conjugates containing Control copolymers cytoplasm degradation delivered delivery systems demonstrated dendrimers drug effect encapsulated endosomal enhanced et al factor Figure formation formulation function gene delivery gene expression Gene Ther gene therapy gene transfer genetic groups higher human immune increase injection interaction levels liposomes lung material matrices mechanism membrane method mice microspheres modified molecular weight molecules naked nanoparticles nonviral nuclear observed oligonucleotides particles pDNA peptide Pharm plasmid DNA polymer polymeric polyplexes potential prepared present properties protection protein ratio receptor reduced release reported response showed shown specific stability stent structure studies surface synthesis targeting therapeutic tissue toxicity transfection efficiency transgene tumor uptake vaccine vectors viral virus vitro vivo