Polymeric Gene Delivery: Principles and ApplicationsMansoor M. Amiji CRC Press, 2004年9月29日 - 704 頁 To treat disease or correct genetic disorders using gene therapy, the most suitable vehicle must be able to deliver genes to the appropriate tissues and cells in the body in a specific as well as safe and effective manner. While viruses are the most popular vehicles to date, their disadvantages include toxicity, limited size of genes they can carry |
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Acad activity adenovirus amine amino antisense applications binding Bioconj biodegradable Biol biological block copolymers cancer cationic lipids cationic polymers cells cellular charge ratio Chem chitosan collagen condensation conjugates cytoplasm cytotoxicity degradation dendrimers DNA complexes DNA delivery drug delivery effect encapsulated endocytosis endosomal enhanced Figure formulation gene delivery gene delivery systems gene expression Gene Ther gene therapy gene transfer genetic hydrogels increase injection interaction intracellular intravenous ligands liposomes liver luciferase lung macromolecules mediated membrane mice microspheres molecular weight molecules naked DNA nanoparticles nanospheres nonviral gene nonviral vectors nuclear nucleic acids oligonucleotides PAAs PAMAM particles pDNA PEGylated peptide Pharm plasmid plasmid DNA PLGA Pluronic poloxamers polycations polyelectrolyte polyethylenimine polylysine polymeric polyplexes potential protein receptor receptor-mediated serum specific stability structure studies surface synthesis synthetic targeting therapeutic tissue toxicity transfection efficiency tumor uptake vaccine viral vectors virus vitro vivo gene zeta potential